期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2021, 期 11, 页码 1758-1762出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100098
关键词
Green solvents; Hydroxylation; β -Ketoesters; MMPP; Tartronic esters
A mild and convenient protocol using cheap and stable magnesium monoperphthalate (MMPP) as the oxidant was developed for the alpha-hydroxylation of alpha-substituted malonates, beta-ketoesters, and beta-ketoamides. The protocol allows for the synthesis of various compounds in good yields at room temperature.
A mild and convenient protocol for the alpha-hydroxylation of alpha-substituted malonates, beta-ketoesters, and beta-ketoamides is disclosed. Cheap and stable magnesium monoperphthalate (MMPP) was effective for a first direct alpha-hydroxylation protocol of the Rubottom oxidation, providing tartronic esters, cyclic alpha-hydroxy beta-ketoesters and amides in good to high yields, when working at room temperature and in ethanol as the solvent. The protocol has been successfully scaled up to gram quantity.
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