One-Pot Synthesis of 5-Amino-1,2,3-triazole Derivatives via Dipolar Azide-Nitrile Cycloaddition and Dimroth Rearrangement under Solvent-Free Conditions

An efficient one-pot methodology for the preparation of 5-amino-1,2,3-triazole derivatives based on the combination of dipolar azide-nitrile cycloaddition with Dimroth rearrangement under solvent-free conditions has been developed.

Automated summary

An efficient one-pot methodology has been developed for the synthesis of 5-amino-1,2,3-triazole derivatives under solvent-free conditions, using a combination of dipolar azide-nitrile cycloaddition and Dimroth rearrangement.