4.5 Article

Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study

期刊

EUROPEAN JOURNAL OF NUTRITION
卷 60, 期 6, 页码 3473-3483

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00394-021-02528-w

关键词

Maternal vitamin D status in pregnancy; Vitamin D in newborn; Mother-infant blood set; Vitamin D deficiency

资金

  1. National Natural Science Foundation of China [81773411]
  2. National Key Research and Development Project of China [2016YFC1305204, 2020YFC2008002]
  3. Medical and Engineering Cooperation Project of Shanghai Jiao Tong University [YG2017ZD15]
  4. Shanghai Children's Health Services Capacity Program [GDEK201708]
  5. Science and Technology Commission Project of Shanghai Pudong New Area [PKJ2017-Y05]
  6. Shanghai Municipal Education CommissionGaofeng Clinical Medicine Grant Support [20152220]
  7. Shanghai Municipal Commission of Science and Technology Program [13JC1403700]
  8. Shanghai Municipal Education Commission [ZXDF089002]
  9. Shanghai Key Laboratory of Psychotic Disorders [13dz2260500, 14-K06]
  10. Shanghai Municipal Health Commission
  11. Shanghai Jiao Tong University School of Medicine
  12. National Human Genetic Resources Sharing Service Platform [2005DKA21300]

向作者/读者索取更多资源

Maternal vitamin D concentrations in each trimester are positively associated with neonatal vitamin D status in cord blood, with the strongest correlation found in the late stage of pregnancy. This suggests that attention to vitamin D nutrition during pregnancy can help prevent vitamin D deficiency in newborns.
Purpose Prenatal vitamin D (VitD) deficiency influences children's health in later life. We aimed to test the associations between maternal VitD status in each of the three trimesters of pregnancy and cord blood 25(OH)D concentrations in newborns. Methods Participants were pregnant women recruited from the Shanghai Birth Cohort (SBC) (n = 1100). Of all the participants, 946 completed the collection of venous blood at early (< 16 weeks, T1), mid- (24-28 weeks, T2), and late (32-34 weeks, T3) pregnancy as well as the corresponding cord blood in the newborns. Maternal serum 25(OH)D concentrations were measured by LC-MS/MS, and the information on confounding factors was obtained through a standardized questionnaire. Results The mean 25(OH)D concentrations at time points T1, T2, T3 in maternal blood and cord blood of the newborns were 26.31 ng/mL, 31.92 ng/mL, 35.62 ng/mL, and 19.77 ng/mL, respectively. Neonatal 25(OH)D level in cord blood was positively correlated with maternal serum 25(OH)D levels at each trimester, and the strongest correlation was found at time point T3. Conclusion Maternal 25(OH)D concentrations at each trimester were positively associated with neonatal VitD status in cord blood, and the strongest correlation was found in the late stage of pregnancy, which could be considered as a sensitive time window. Attention should be paid to the nutritional status of VitD during pregnancy to better prevent the VitD deficiency in neonates.

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