期刊
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
卷 49, 期 1, 页码 246-256出版社
SPRINGER
DOI: 10.1007/s00259-021-05248-9
关键词
Translocator protein 18 kDa (TSPO); Positron emission tomography (PET); Kinetic modeling; Inflammation
资金
- University of Edinburgh
- Intramural Research Program of the National Institute of Mental Health, National Institutes of Health [ZIAMH002852]
- Siemens Healthcare Ltd.
This review focuses on the challenges associated with the quantification of TSPO PET images in the human brain, with a discussion of different methods and their advantages and drawbacks. Researchers are advised to understand the various quantification methods available and to choose the most appropriate one based on their research needs.
Purpose Translocator protein 18-kDa (TSPO) imaging with positron emission tomography (PET) is widely used in research studies of brain diseases that have a neuro-immune component. Quantification of TSPO PET images, however, is associated with several challenges, such as the lack of a reference region, a genetic polymorphism affecting the affinity of the ligand for TSPO, and a strong TSPO signal in the endothelium of the brain vessels. These challenges have created an ongoing debate in the field about which type of quantification is most useful and whether there is an appropriate simplified model. Methods This review focuses on the quantification of TSPO radioligands in the human brain. The various methods of quantification are summarized, including the gold standard of compartmental modeling with metabolite-corrected input function as well as various alternative models and non-invasive approaches. Their advantages and drawbacks are critically assessed. Results and conclusions Researchers employing quantification methods for TSPO should understand the advantages and limitations associated with each method. Suggestions are given to help researchers choose between these viable alternative methods.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据