相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells
Justin Cidado et al.
CLINICAL CANCER RESEARCH (2020)
AMG-176, an Mcl-1 Antagonist, Shows Preclinical Efficacy in Chronic Lymphocytic Leukemia
Xue Yi et al.
CLINICAL CANCER RESEARCH (2020)
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies
Darren C. Phillips et al.
LEUKEMIA (2020)
Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy
Jonathan Chou et al.
CANCER DISCOVERY (2020)
Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity
Junyu Xu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors
Pabitra K. Parua et al.
NATURE CHEMICAL BIOLOGY (2020)
Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update
Tizhi Wu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia
Daniel A. Luedtke et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Efficacy of combined CDK9/13ET inhibition in preclinical models of MLL-rearranged acute leukemia
Hannah McCalmont et al.
BLOOD ADVANCES (2020)
CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia
Muhammed H. Rahaman et al.
INVESTIGATIONAL NEW DRUGS (2019)
Targeting CDK9 for treatment of colorectal cancer
Muhammed H. Rahaman et al.
MOLECULAR ONCOLOGY (2019)
CDK9: a signaling hub for transcriptional control
Curtis W. Bacon et al.
TRANSCRIPTION-AUSTIN (2019)
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
Calla M. Olson et al.
NATURE CHEMICAL BIOLOGY (2018)
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
Beilei Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
Sean Caenepeel et al.
CANCER DISCOVERY (2018)
Antitumor action of CDK inhibitor LS-007 as a single agent and in combination with ABT-199 against human acute leukemia cells
Shao Xie et al.
ACTA PHARMACOLOGICA SINICA (2016)
Overview of CDK9 as a target in cancer research
Fatima Morales et al.
CELL CYCLE (2016)
Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy
Yogesh A. Sonawane et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine
Elisabeth Walsby et al.
ONCOTARGET (2014)
Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents
Hao Shao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure-Activity Relationship, and Anticancer Activities
Hao Shao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9 Implications for drug design and development
Valentina Caracciolo et al.
CELL CYCLE (2012)
Discovery and Characterization of 2-Anilino-4-(Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
Shudong Wang et al.
CHEMISTRY & BIOLOGY (2010)
Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones
Sylvain Grosjean et al.
TETRAHEDRON (2010)
The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Simak Ali et al.
CANCER RESEARCH (2009)
Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights
Robert Filler et al.
FUTURE MEDICINAL CHEMISTRY (2009)
Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases
Gaetano Romano et al.
CELL CYCLE (2008)
Unique Biology of Mcl-1: Therapeutic Opportunities in Cancer
Gordon Shore et al.
CURRENT MOLECULAR MEDICINE (2008)
Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology
Shudong Wang et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Fluorine in pharmaceuticals:: Looking beyond intuition
Klaus Mueller et al.
SCIENCE (2007)
Myeloid cell leukemia-1 as a therapeutic target
Arthur M. Mandelin et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9
Tadashi Shimamura et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Mammalian cyclin-dependent kinases
M Malumbres et al.
TRENDS IN BIOCHEMICAL SCIENCES (2005)
Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death
R Chen et al.
BLOOD (2005)
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis
A Nencioni et al.
BLOOD (2005)
Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors
C McInnes et al.
CHEMISTRY & BIOLOGY (2004)
2-anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: Synthesis, SAR analysis, X-ray crystallography, and biological activity
SD Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Cellular control of gene expression by T-type cyclin/CDK9 complexes
J Garriga et al.
GENE (2004)
Atropisomerism, biphenyls, and fluorine: A comparison of rotational barriers and twist angles
F Leroux
CHEMBIOCHEM (2004)
Synthesis and characterisation of N,N-disubstituted 2-amino-5-acylthiophenes and 2-amino-5-acylthiazoles
A Noack et al.
TETRAHEDRON (2002)
The novel syntheses of alpha-trifluoromethylated ketones from beta-bromoenol phosphates
XG Huang et al.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2001)
分享论文
