期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 51, 期 5, 页码 1062-1070出版社
WILEY
DOI: 10.1002/eji.202048984
关键词
Animal models; Host; pathogen interaction; Immune responses; Mouse Hepatitis Virus; SARS‐ CoV‐ 2
类别
资金
- Swiss National Science Foundation [180011, 177208, 182583]
- Novartis Foundation for Biomedical Research
Coronaviruses can cause various diseases including lung, CNS, enteric, and hepatic diseases. The emergence of SARS-CoV, MERS-CoV, and SARS-CoV-2 has shown the potential for severe respiratory and systemic diseases caused by coronaviruses. Studying mouse hepatitis virus (MHV) provides insights into coronavirus virulence factors and host mechanisms of antiviral immunity.
Coronaviruses (CoVs) represent enveloped, ss RNA viruses with the ability to infect a range of vertebrates causing mainly lung, CNS, enteric, and hepatic disease. While the infection with human CoV is commonly associated with mild respiratory symptoms, the emergence of SARS-CoV, MERS-CoV, and SARS-CoV-2 highlights the potential for CoVs to cause severe respiratory and systemic disease. The devastating global health burden caused by SARS-CoV-2 has spawned countless studies seeking clinical correlates of disease severity and host susceptibility factors, revealing a complex network of antiviral immune circuits. The mouse hepatitis virus (MHV) is, like SARS-CoV-2, a beta-CoV and is endemic in wild mice. Laboratory MHV strains have been extensively studied to reveal coronavirus virulence factors and elucidate host mechanisms of antiviral immunity. These are reviewed here with the aim to identify translational insights for SARS-CoV-2 learned from murine CoVs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据