The significance of left ventricular ejection time in heart failure with reduced ejection fraction

Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET. [GRAPHICS]

Automated summary

LVET is the time interval from aortic valve opening to closure in which the left ventricle ejects blood into the aorta. It has long been used to assess left ventricular function and contractility, but recent interest focuses on its use as a measure of therapeutic action for heart failure patients. This review provides an overview of LVET measurement methods, mechanistic understanding, association with outcomes, mechanisms behind LVET shortening in heart failure, and potential drug implications.