Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-beta-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). bla(NDM-1) (45; 30.2%) and bla(OXA-48) (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

Automated summary

The study conducted whole genome sequencing and multi-locus sequence typing on 149 carbapenem-resistant Enterobacterales obtained from clinical samples between April 2014 and November 2017. The most common species were Klebsiella pneumoniae and Escherichia coli, with genes encoding metallo-beta-lactamases and OXA-48-like enzymes being frequently detected in the isolates.