The use of multi-pronged screening strategy to understand the epidemiology of carbapenemase-producing Enterobacteriaceae in Hong Kong: transition from epidemic to endemic setting

A multi-pronged carbapenemase-producing Enterobacteriaceae (CPE) screening strategy was implemented in Hong Kong West healthcare network. Of 199,192 fecal specimens from 77,194 patients screening from 1 July 2011 to 30 June 2019, the incidence of CPE per 1000 patient admission significantly increased from 0.01 (2012) to 1.9 (2018) (p<0.01). With appropriate infection control measures, the incidence of nosocomial CPE per 1000 CPE colonization day decreased from 22.34 (2014) to 10.65 (2018) (p=0.0094). Exposure to wet market for purchasing raw pork (p=0.007), beef (p=0.017), chicken (p=0.026), and vegetable (p=0.034) for >3 times per week significantly associated with community acquisition of CPE. Strategic CPE control measures should be implemented in both the hospital and the community.

Automated summary

A multi-pronged screening strategy for carbapenemase-producing Enterobacteriaceae (CPE) was implemented in the West healthcare network in Hong Kong. The incidence of CPE increased significantly from 2012 to 2018, but appropriate infection control measures helped to reduce the incidence of nosocomial CPE. People who frequently purchased raw meat and vegetables from wet markets were found to have a higher risk of community acquisition of CPE. Strategic control measures for CPE should be implemented in both hospital and community settings.