期刊
EUROPEAN JOURNAL OF CANCER
卷 145, 期 -, 页码 11-18出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2020.11.031
关键词
Price; Value; Clinical added benefit; Drugs; Oncology
类别
资金
- IMeRA Institute
- Aix-Marseille Univ
- SIRIC, Marseille
The study found a weak correlation between drug prices and added therapeutic benefit for drugs to treat solid tumors in France. Prices increased substantially even for drugs with no added benefit, but the correlation between benefit and prices was stronger for first indications.
Background: Increasing drug prices strains budgets. Assessing the relation between added benefit and prices can help clinical decision-making and resource allocation. Methods: We assessed, over a period of 13 years, the relation between added therapeutic benefit and prices for drugs to treat solid tumours in France using the French High Authority of Health Scale (ASMR) and the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (MCBS). Results: In total, 36 medications were approved for 68 indications. There was a weak correlation between ASMR and MCBS scales (Spearman's vertical bar rho vertical bar = 0.28). Drugs had low added benefit on both ASMR (71%) and MCBS (49%). Mean monthly price for new drugs was (sic)4616 (S.D., (sic)3096), ranging from (sic)1795 to (sic)19,675 and increased by 47% comparing 2004-2012 with 2013-2017. The mean monthly price difference of new drugs over their comparator was (sic)3700 (S.D., (sic)3934) ranging between a (sic)13,853 decrease and a (sic)19,675 increase. There was a weak but statistically significant correlation between ASMR and price (vertical bar rho vertical bar = 0.35, p = 0.004) and between MCBS and price (vertical bar rho vertical bar = 0.33, p = 0.005). Correlations between added benefit and prices were similar or higher for first indications (ASMR, vertical bar rho vertical bar = 0.37, p = 0.030; MCBS, vertical bar rho vertical bar = 0.48, p = 0.004). In first indications, mean monthly prices increased (sic)3954 for drugs without ASMR added benefit. The mean annual price and price increase for first indications offering no ASMR benefit was (sic)57,312 and (sic)47,448, respectively. Conclusion: Prices and benefit are weakly correlated. However, prices increased substantially even for drugs with no added benefit. (C) 2020 Published by Elsevier Ltd.
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