4.4 Article

Etanercept rescues cognitive deficits, depression-like symptoms, and spike-wave discharge incidence in WAG/Rij rat model of absence epilepsy

期刊

EPILEPSY & BEHAVIOR
卷 115, 期 -, 页码 -

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2020.107532

关键词

Absence epilepsy; Comorbidity; TNF-alpha; Etanercept; WAG/Rij; SWD

资金

  1. Scientific Research Projects Coordination Unit of Kocaeli University [KOU BAP 2016/33]

向作者/读者索取更多资源

Pro-inflammatory cytokines may mediate the onset and comorbid symptoms of absence epilepsy in WAG/Rij rats, while treatment with etanercept (a tumor necrosis factor inhibitor) can improve cognitive deficits and depression-like behavior, as well as reduce the frequency of spike-wave discharges.
Pro-inflammatory cytokines have been shown to be associated with the development of seizures in the WAG/Rij rat model of absence epilepsy. Importantly, WAG/Rij rats also exhibit cognitive deficits and depression-like behaviors. It is possible that pro-inflammatory cytokines mediate these comorbid conditions of absence epilepsy given their well-established effects on cognition and affective responses. The current study investigated the potential therapeutic effect of etanercept (tumor necrosis factor inhibitor) on cognitive impairment, depression-like behavior, and spike-wave discharges (SWDs) typically observed in the WAG/Rij rats. Eight-month-old male WAG/Rij rats and Wistar controls were tested in Morris water maze (MWM), passive avoidance (PA), forced swimming, sucrose preference, and locomotor activity tests, and electroencephalogram (EEG) recordings were taken from a separate group of WAG/Rij rats after 8 weeks of etanercept or vehicle treatment. Consistent with earlier work, WAG/Rij rats exhibited cognitive deficits and depression-like behavior. From these, the cognitive deficits and despair-like behavior were rescued by etanercept administration, which also reduced the frequency of SWDs without affecting their duration. Our results support the hypothesis that pro-inflammatory cytokines mediate the absence seizures and comorbid symptoms of absence epilepsy. (C) 2020 Elsevier Inc. All rights reserved.

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