期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 28, 期 27, 页码 36060-36068出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-021-13267-0
关键词
Bisphenol A; Low concentration; Ovarian cancer; Cell proliferation; Metastasis; Estrogen receptor-α
资金
- State Key Laboratory for Environmental Chemistry and Ecotoxicology [KF2012-4]
- National Natural Science Foundation of China [21407172, 21577095]
The study found that BPA can stimulate proliferation and metastasis of ovarian cancer cells by upregulating various proteins through the ER alpha signaling pathway. These results provide new insights into the carcinogenic effects of BPA on ovarian cancer.
Bisphenol A (BPA) is a widely used raw material that can be detected both in the environment and in the human body. Due to its estrogen-like effects, wide concerns have been raised about the potential role of BPA in the initiation and development of hormone-dependent cancers. Ovarian cancer is the most common reproductive system cancer and has a high mortality rate in women. Despite recent investigations into BPA's carcinogenic effects, studies on its role in ovarian cancer development remain limited. In this study, we aimed to assess the effect of BPA at various environmentally relevant concentrations on proliferation and metastasis of ovarian cancer cells. We discovered that BPA can stimulate proliferation of OVCAR-3 ovarian cancer cells after exposure for up to 5 days. Strikingly, BPA enhanced ovarian cancer cell migration, invasion, and adhesion (to vascular endothelial cells) through upregulation of matrix metalloproteinase-2 (MMP-2), MMP-9, and intercellular cell adhesion molecule-1 (IMAC-1). The stimulatory effects of BPA on cancer cell proliferation and metastasis were reversed by treatment with an ER alpha inhibitor, but not by treatment with an ER beta inhibitor. Together, these results suggest that BPA induces proliferation and metastasis of ovarian cancer cells through ER alpha signaling pathways. This study provides new insights into the carcinogenic effects of BPA with regard to ovarian cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据