期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 28, 期 14, 页码 17044-17067出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-021-12985-9
关键词
Epigenetics; Electronic cigarettes; DNA methylation; Histone modifications; ncRNA
资金
- National Natural Science Foundation of China [31771582, 31271445]
- Guangdong Natural Science Foundation of China [2017A030313131]
- Thousand, Hundred, and Ten project of the Department of Education of Guangdong Province of China
- Basic and Applied Research Major Projects of Guangdong Province of China [2017KZDXM035, 2018KZDXM036]
- Yang Fan Project of Guangdong Province of China
Research has shown that e-cigarette aerosols contain many toxic compounds that can adversely affect the human epigenome. Ingredients in e-cigarettes such as nicotine, volatile organic compounds, etc., can also affect DNA methylation, leading to the development of diseases.
Electronic cigarettes (e-cigarettes), since they do not require tobacco combustion, have traditionally been considered less harmful than conventional cigarettes (c-cigarettes). In recent years, however, researchers have found many toxic compounds in the aerosols of e-cigarettes, and numerous studies have shown that e-cigarettes can adversely affect the human epigenome. In this review, we provide an update on recent findings regarding epigenetic outcomes of e-cigarette aerosols. Moreover, we discussed the effects of several typical e-cigarette ingredients (nicotine, tobacco-specific nitrosamines, volatile organic compounds, carbonyl compounds, and toxic metals) on DNA methylation, histone modifications, and noncoding RNA expression. These epigenetic effects could explain some of the diseases caused by e-cigarettes. It also reminds the public that like c-cigarettes, inhaling e-cigarette aerosols could also be accompanied with potential epigenotoxicity on the human body.
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