期刊
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
卷 40, 期 9, 页码 507-516出版社
EDICIONES DOYMA S A
DOI: 10.1016/j.eimc.2021.01.013
关键词
Covid-19; Convalescent plasma; Humoral immunodeficiency; Rituximab; Obinutuzumab
This article discusses the use of COVID-19 convalescent plasma (CCP) in patients with humoral immunodeficiency. The study suggests that CCP can improve clinical symptoms and shorten the duration of the disease for patients with congenital primary immunodeficiency or those on treatment with anti CD20 antibodies.
Patients lacking humoral response have been suggested to develop a less severe COVID-19, but there are some reports with a prolonged, relapsing or deadly course. From April 2020, there is growing evidence on the benefits of COVID-19 convalescent plasma (CCP) for patients with humoral immunodeficiency. Most of them had a congenital primary immunodeficiency or were on treatment with anti CD20 antibodies. We report on three patients treated in our hospital and review thirty-one more cases described in the literature. All patients but three resolved clinical picture with CCP. A dose from 200 to 800 ml was enough in most cases. Antibody levels after transfusion were negative or low, suggesting consumption of them in SARS-CoV-2 neutralization. These patients have a protracted clinical course shortened after CCP. CCP could be helpful for patients with humoral immunodeficiency. It avoid relapses and chronification. CCP should be transfused as early as possible in patients with COVID-19 and humoral immunodeficiency.(c) 2021 Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. Published by Elsevier Espana, S.L.U. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据