期刊
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
卷 45, 期 3, 页码 539-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ecl.2016.04.006
关键词
Obesity; Bariatric surgery; Sleeve gastrectomy; Roux-en-Y gastric bypass; Gut hormones; Bile acids; Eating behavior; Microbiome
资金
- Department of Health [RP-2015-06-005] Funding Source: Medline
- National Institute for Health Research [ACF-2015-18-005] Funding Source: researchfish
Bariatric surgery is the only effective treatment for severe obesity. Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the most commonly performed procedures, lead to sustained weight loss, improvements in obesity-related comorbidities and reduced mortality. In humans, the main driver for weight loss following RYGB and SG is reduced energy intake. Reduced appetite, changes in subjective taste and food preference, and altered neural response to food cues are thought to drive altered eating behavior. The biological mediators underlying these changes remain incompletely understood, but changes in gut-derived signals, as a consequence of altered nutrient and/or biliary flow, are key candidates.
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