期刊
ENDOCRINOLOGY
卷 162, 期 7, 页码 -出版社
ENDOCRINE SOC
DOI: 10.1210/endocr/bqab052
关键词
testicular extracellular vesicles; spermatogonial stem cell; proliferation
资金
- National Key Research and Development Program of China [2018YFC1003500]
- National Natural Science Foundation of China [81720108017, 81901536]
The study revealed the presence of extracellular vesicles in the basal compartment of seminiferous tubules in mice, rats, rabbits, and humans, which are secreted by spermatogonia and taken up by SSCs. These extracellular vesicles purified from Thy1-positive spermatogonia were found to suppress the proliferation of SSCs without inducing apoptosis.
The self-renewal of mammalian spermatogonial stem cells (SSCs) supports spermatogenesis to produce spermatozoa, and this is precisely controlled in a stem niche microenvironment in the seminiferous tubules. Although studies have revealed the role of the surrounding factors in SSCs, little is known about whether the division of SSCs is controlled by extracellular vesicles. Here, extracellular vesicles were found in the basal compartment of seminiferous tubules in mouse, rat, rabbit and human testes. In the mice, the testicular extracellular vesicles are secreted by spermatogonia and are taken up by SSCs. Further, the extracellular vesicles from thy1-positive spermatogonia were purified by anti-Thy1-coupled magnetic beads, which suppress their proliferation of SSCs but do not lead to the apoptosis in vitro.
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