期刊
EMBO JOURNAL
卷 40, 期 7, 页码 -出版社
WILEY
DOI: 10.15252/embj.2020106922
关键词
autophagy; endocytosis; ESCRT; lysosome; membrane repair
资金
- Research Council of Norway [302994]
- South-Eastern Norway Regional Health Authority [2016087, 2018043]
- Norwegian Cancer Society [182698]
- European Research Council [788954]
- Research Council of Norway through its Centres of Excellence funding scheme [262652]
- European Research Council (ERC) [788954] Funding Source: European Research Council (ERC)
The compartmentalization of eukaryotic cells is essential for their viability, with membranes forming boundaries between organelles and the cytosol. Cellular membranes can be compromised by various factors, but there are evolved mechanisms like membrane scission and endocytosis to maintain membrane integrity.
The compartmentalization of eukaryotic cells, which is essential for their viability and functions, is ensured by single or double bilayer membranes that separate the cell from the exterior and form boundaries between the cell's organelles and the cytosol. Nascent nuclear envelopes and autophagosomes, which both are enveloped by double membranes, need to be sealed during the late stage of their biogenesis. On the other hand, the integrity of cellular membranes such as the plasma membrane, lysosomes and the nuclear envelope can be compromised by pathogens, chemicals, radiation, inflammatory responses and mechanical stress. There are cellular programmes that restore membrane integrity after injury. Here, we review cellular mechanisms that have evolved to maintain membrane integrity during organelle biogenesis and after injury, including membrane scission mediated by the endosomal sorting complex required for transport (ESCRT), vesicle patching and endocytosis.
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