期刊
ELECTROCHIMICA ACTA
卷 368, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2020.137420
关键词
Electrochemical cross-coupling; Oxidation; Design of experiments; Reaction optimization; Electrolysis
资金
- Deutsche Forschungsgemeinschaft (DFG) [FOR 2982, Wa1276/23-1]
This study presents a new strategy for optimizing electro-organic reactions using Design of Experiments (DoE), successfully increasing the yield of an example reaction to 85% and identifying various suitable reaction conditions through linear regression analysis.
The optimization of electro-organic reactions poses a challenge due to the various parameters involved. Quite often those parameters are not independent from each other, leading the experimental scientist using linear approaches into an optimization loophole. We report a strategy for the optimization of the anodic oxidative dehydrogenative C,C cross-coupling reactions for the synthesis of biphenols based on Design of Experiments (DoE), which overcomes the drawbacks of linear optimization approaches. Using a fractional design, we increased the yield of a long-time investigated example reaction from 44% up to 85% and point out different suitable reaction conditions through to linear regression of the parameter space investigated. (C) 2020 Elsevier Ltd. All rights reserved.
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