Synthesis of a multichromophoric array by sequential CuAAC reactions

An easily synthesized alpha-hydroxy-beta-azidotetrazole scaffold was used to build a three dimensional polychromic system. Different chromophores (coumarin, BODIPY and distyryl BODIPY) were incorporated into the structure by using sequential CuAAC reactions to form a series of dyads and a triad. A computational study of the resulting arrays showed that the predominant conformations brought the substituents into close spatial proximity. The triad exhibited FRET behaviour with notably efficient energy transfer values.

Automated summary

An easily synthesized alpha-hydroxy-beta-azidotetrazole scaffold was used to build a three dimensional polychromic system, which exhibited notably efficient energy transfer values.