期刊
DRUG DEVELOPMENT RESEARCH
卷 82, 期 7, 页码 1055-1062出版社
WILEY
DOI: 10.1002/ddr.21812
关键词
pyrazole– tetrazole; spectroscopy; vasorelaxant activity
The synthesis of new functionalized tetrazole-pyrazole compounds was reported, fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was investigated, with one compound showing a high effect at 10(-4) M concentration. This effect was partially endothelium-dependent, and the vasorelaxant pattern of this compound was similar to that of verapamil.
The synthesis of new functionalized tetrazole-pyrazole compounds is reported. They were fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was also investigated. All compounds showed a good vasorelaxant activity but the Compound 6 ethyl 1-((2-(3-bromopropyl)-2H-tetrazol-5-yl)methyl)-5-methyl-1H-pyrazole-3-carboxylate seems to have the highest effect, which reached 70% at 10(-4) M concentration. This effect was partially endothelium-dependent; also, the vasorelaxant pattern of this compound was quite similar to that of the verapamil.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据