Synthesis and characterization of new pyrazole-tetrazole derivatives as new vasorelaxant agents

The synthesis of new functionalized tetrazole-pyrazole compounds is reported. They were fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was also investigated. All compounds showed a good vasorelaxant activity but the Compound 6 ethyl 1-((2-(3-bromopropyl)-2H-tetrazol-5-yl)methyl)-5-methyl-1H-pyrazole-3-carboxylate seems to have the highest effect, which reached 70% at 10(-4) M concentration. This effect was partially endothelium-dependent; also, the vasorelaxant pattern of this compound was quite similar to that of the verapamil.

Automated summary

The synthesis of new functionalized tetrazole-pyrazole compounds was reported, fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was investigated, with one compound showing a high effect at 10(-4) M concentration. This effect was partially endothelium-dependent, and the vasorelaxant pattern of this compound was similar to that of verapamil.