期刊
DRUG AND ALCOHOL DEPENDENCE
卷 220, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2021.108511
关键词
Cytokines; Chemokines; Alcohol; Opioids; Cocaine; Methamphetamine
资金
- NIDA/NIH [R01 DA039139, R01 DA045499, R01 DA051205-01, P30 DA013429]
This review discusses the role of cytokines and chemokines in the rewarding and reinforcing effects of drugs, as well as their potential as therapeutic targets for substance use disorders. Emerging cytokine- and chemokine-based therapeutic strategies show promise for impacting treatment outcomes.
Efficacious pharmacotherapies for the treatment of substance use disorders need to be expanded and improved. Non-neuronal cells, particularly astrocytes and microglia, have emerged as therapeutic targets for the development of pharmacotherapies to treat dependence and relapse that accompanies chronic drug use. Cytokines and chemokines are neuroimmune factors expressed in neurons, astrocytes, and microglia that demonstrate promising clinical utility as therapeutic targets for substance use disorders. In this review, we describe a role for cytokines and chemokines in the rewarding and reinforcing effects of alcohol, opioids, and psychostimulants. We also discuss emerging cytokine- and chemokine-based therapeutic strategies that differ from conventional strategies directed toward transporters and receptors within the dopamine, glutamate, GABA, serotonin, and GABA systems.
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