期刊
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
卷 496, 期 1, 页码 18-21出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1607672921010063
关键词
Xmas-2; Orc3; TREX-2; mRNA export
资金
- Russian Foundation for Basic Research [19-04-00861]
The TREX-2 protein complex, essential for mRNA export, interacts with the ORC complex. Specifically, the Xmas-2 protein serves as a platform for TREX-2 assembly and interacts with Orc3, requiring a C-terminal region of Xmas-2.
The TREX-2 protein complex is the key participant in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a protein complex of D. melanogaster consisting of TREX-2 and ORC complexes was purified. It was shown that, in the TREX-2-ORC complex, the Xmas-2 protein, which is the platform for TREX-2 assembly, interacts with the Orc3 protein. The aim of this work was to investigate what regions of the Xmas-2 amino acid sequence are involved in the interaction with Orc3. It was shown that the interaction of Xmas-2 with Orc3 requires a C-terminal region of Xmas-2 located downstream of the CID domain.
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