4.0 Article

Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms

期刊

DOCUMENTA OPHTHALMOLOGICA
卷 143, 期 1, 页码 53-60

出版社

SPRINGER
DOI: 10.1007/s10633-021-09822-2

关键词

Visual electrophysiology; Full-field ERG; Light adaptation; Retina; Pseudorandom stimulation

资金

  1. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq- Programa de Apoio aos Nucleos de Excelencia- PRONEX / Fundacao Amazonia de Amparo a Estudos e Pesquisa do Para-FAPESPA [316,799/2009]
  2. CNPq [486,545/2012-1, 431,748/2016-0]
  3. Financiadora de Estudos e Projetos -FINEP- Instituto Brasileiro de Neurociencia -IBN Net [1723]
  4. CNPq fellowship
  5. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -CAPES
  6. Programa Nacional de Pos Doutorado-PNPD/CAPES post-doctoral fellowship

向作者/读者索取更多资源

This study investigated the amplitude and time course of pseudorandom ffERG during light adaptation. Results showed that different ffERG components had different mechanisms of adaptation to retinal light. The K-1 ffERG was influenced by retinal mechanisms with intermediate- to long-term light adaptation, while the K-2.1 ffERG was influenced by retinal mechanisms with a fast light adaptation course.
Purpose To investigate the magnitude and time course of pseudorandom ffERG during light adaptation. Methods Ten healthy subjects (26 +/- 10.1 years) underwent 20 min of dark adaptation, and then the ffERG was evoked by pseudorandom flash sequences (4 ms per flash, 3 cd.s/m(2)) driven by m-sequences (2(10)-1 stimulus steps) using Veris Science software and a Ganzfeld dome over a constant field of light adaptation (30 cd/m(2)). The base period of the m-sequence was 50 ms. Each stimulation sequence lasting 40 s was repeated at 0, 5, 10, 15 and 20 min of light adaptation. Relative amplitude and latency (corrected by values found at 0 min) of the three components (N1, P1, and N2) of first-order (K-1) and first slice of the second-order (K-2.1) kernel at 5 time points were evaluated. An exponential model was fitted to the mean amplitude and latency data as a function of the light adaptation duration to estimate the time course (tau) of the light adaptation for each component. Repeated one-way ANOVA followed by Tukey post-test was applied to the amplitude and latency data, considering significant values of p < 0.05. Results Regarding the K-1 ffERG, N1 K-1, P1 K-1, and N2 K-1 presented an amplitude increase as a function of the light adaptation (N1 K-1 tau value = 2.66 min +/- 4.2; P1 K-1 tau value = 2.69 min +/- 2.10; and N2 K-1 tau value = 3.49 min +/- 2.96). P1 K-1 and N2 K-1 implicit time changed as a function of the light adaptation duration (P1 K-1 tau value = 3.61 min +/- 5.2; N2 K-1 tau value = 3.25 min +/- 4.8). N1 K-1 had small implicit time changes during the light adaptation. All the K-2,K-1 components also had nonsignificant changes in amplitude and implicit time during the light adaptation. Conclusions Pseudorandom ffERGs showed different mechanisms of adaptation to retinal light. Our results suggest that K-1 ffERG is generated by retinal mechanisms with intermediate- to long-term light adaptation, while K-2.1 ffERG is generated by retinal mechanism with fast light adaptation course.

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