期刊
DIABETES TECHNOLOGY & THERAPEUTICS
卷 23, 期 7, 页码 512-516出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dia.2020.0619
关键词
Carbohydrate; hypoglycemia; Predictive low-glucose suspend; Type 1 diabetes
资金
- Eli Lilly and Company
A study found that current guidelines for low blood sugar treatment do not take into account the reduced insulin during predictive low blood sugar suspensions, suggesting the need to adjust guidance to reduce the amount of carbohydrates needed for low blood sugar rescue.
Current guidelines recommend 15-20 g of carbohydrate (CHO) for treatment of mild to moderate hypoglycemia. However, these guidelines do not account for reduced insulin during suspensions with predictive low-glucose suspend (PLGS). We assessed insulin suspensions, hypoglycemic events, and CHO treatment during a 20-h inpatient evaluation of an investigational system with a PLGS feature, including an overnight basal up-titration period to activate the PLGS. Among 10 adults with type 1 diabetes, there were 59 suspensions; 7 suspensions were associated with rescue CHO and 5 with hypoglycemia. Rescue treatment consisted of median 9 g CHO (range: 5-16 g), with no events requiring repeat CHO. No rescue CHO were given during or after insulin suspension for the overnight basal up-titration. To minimize rebound hyperglycemia and needless calorie intake from hypoglycemia overtreatment, updated guidance for PLGS systems should reflect possible need to reduce CHO amounts for hypoglycemia rescue associated with an insulin suspension. The clinical trial was registered with ClinicalTrials.gov (NCT03890003).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据