期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 172, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2020.108645
关键词
diabetes mellitus; gut microbiome; skin microbiome
资金
- National Natural Science Foundation of China for Young Scholars [81600648]
This review summarizes the association between gut and skin microbiota and diabetes mellitus (DM), highlighting their roles in the proinflammatory status of DM. Although there is evidence of a connection causing the same activated innate immune response, further studies are needed to explore the mechanism. These findings could provide insight for future DM prevention, diagnosis and treatment.
The microbiome is greatly significant for immune system development and homeostasis. Dysbiosis in gut microbial composition and function is linked to immune responses and the development of metabolic diseases, including diabetes mellitus (DM). However, skin microbiome changes in diabetic patients and their role in DM are poorly elucidated. In this review, we summarize recent findings about the association between the gut and skin microbiota and DM, highlighting their roles in the proinflammatory status of DM. Moreover, although there is evidence that the connection between the gut and skin causes the same activated innate immune response, additional studies are needed to explore the mechanism. These findings might inform future DM prevention, diagnosis and treatment. CO 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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