The study reveals that the SARS-CoV-2 protein ORF3a disrupts autophagy by interfering with the fusion between autophagosomes and lysosomes, through dysregulation of the HOPS complex.
Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex.
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