期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 115, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2020.103879
关键词
Heligmosomoides polygyrus; Dendritic cells; Autoimmunity; Colitis
资金
- National Science Center, POLAND [2013/09/B/NZ6/00653, 2017/25/N/NZ6/01523]
In an inflammatory environment, the mouse intestinal parasite adaptively affects dendritic cell function, exacerbating inflammatory colitis symptoms.
The mouse intestinal parasite Heligmosomoides polygyrus demonstrates adaptation to the inflammatory milieu as a result of colitis induced by dextran sulphate sodium (DSS). Nematodes from mice with colitis had different effects on dendritic cells than nematodes from mice without colitis. Immature JAWSII cells pre-exposed to L4 stage H. polygyrus from DSS-treated mice were adoptively transferred to mice with induced colitis. After two days, a higher disease activity index, macroscopic damage score and colon histology score were observed. MLN T cells isolated nine days after transfer demonstrated proinflammatory IFN-gamma and IL-17 production. Transfer of JAWSII stimulated with male or female L4 larvae from a control invasion resulted in a slight improvement of colitis; in addition, dendritic cells exposed to H. polygyrus female L4 larvae, provoked migration of CD8(+)CD25(+) T cells from MLN to the colon. Nematodes from an inflammatory environment changed cytokine production by dendritic cells. Inflammatory milieu changing nematode immunomodulatory activity affects dendritic cell functions, which offers new insight into the helminth-host relationship.
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