期刊
DEVELOPMENT
卷 148, 期 6, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.190785
关键词
Branching morphogenesis; Cytoskeleton; Actomyosin contractility; Mechanotransduction; Submandibular gland
资金
- National Research Foundation of Korea grant at Seoul National University [NRF-2018R1A2B3005113]
The study reported a mechanogenetic role of the actomyosin complex in branching morphogenesis, revealing the importance of force distribution for promoting the branching process, and the crucial genes regulated by YAP and TAZ for the distribution of epithelial progenitor cells in epithelial organs.
The actomyosin complex plays crucial roles in various life processes by balancing the forces generated by cellular components. In addition to its physical function, the actomyosin complex participates in mechanotransduction. However, the exact role of actomyosin contractility in force transmission and the related transcriptional changes during morphogenesis are not fully understood. Here, we report a mechanogenetic role of the actomyosin complex in branching morphogenesis using an organotypic culture system of mouse embryonic submandibular glands. We dissected the physical factors arranged by characteristic actin structures in developing epithelial buds and identified the spatial distribution of forces that is essential for buckling mechanism to promote the branching process. Moreover, the crucial genes required for the distribution of epithelial progenitor cells were regulated by YAP and TAZ through a mechanotransduction process in epithelial organs. These findings are important for our understanding of the physical processes involved in the development of epithelial organs and provide a theoretical background for developing new approaches for organ regeneration.
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