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Neurotrophic factors and their receptors in lung development and implications in lung diseases

期刊

CYTOKINE & GROWTH FACTOR REVIEWS
卷 59, 期 -, 页码 84-94

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2021.01.008

关键词

Neurotrophic factors; Receptors; Lung; Development; Respiratory diseases

资金

  1. Grass Center for Drug Design and Synthesis of Novel Therapeutics
  2. David R. Bloom Center of Pharmacy
  3. Adolph and Klara Brettler Medical Research Center at the Hebrew University of Jerusalem, Israel
  4. Temple University

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This review explores the role of neurotrophins in neurogenesis, vasculogenesis, and embryonic development of the respiratory system, as well as their implications for respiratory diseases.
Although lung innervation has been described by many studies in humans and rodents, the regulation of the respiratory system induced by neurotrophins is not fully understood. Here, we review current knowledge on the role of neurotrophins and the expression and function of their receptors in neurogenesis, vasculogenesis and during the embryonic development of the respiratory tree and highlight key implications relevant to respiratory diseases.

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