Administration of Antioxidants in Infertile Male: When it may have a Detrimental Effect?

Background & Objective: Significant advances in the field of male infertility have been witnessed during the last years. Given the well-known detrimental effects of reactive oxygen species (ROS), the administration of antioxidants has emerged as a promising solution for oxidative stress (OS)-induced male infertility. Nevertheless, this perception seems largely oversimplified, and the existing literature fails to recognize a notable superiority of the excessive use of these widely available nutritional compounds. Taking into consideration that several trials have shed light on the so-called antioxidant paradox phenomenon, we recognize that over-the-counter consumption of such supplements might be harmful. Methods: The relevant studies indexed in PubMed, Google Scholar and Scopus databases, published until September 2019 were identified and reported. Conclusion: In this setting, we acknowledge that there is an urgent need for more elaborate studies in the future that will efficiently elucidate the risks and benefits of antioxidants on semen parameters and their impact on fertility potential.

Automated summary

Although antioxidants have emerged as a promising solution for male infertility induced by oxidative stress, the excessive use of these compounds may be harmful. Further elaborate studies are needed in the future to explore the effects of antioxidants on semen parameters and fertility potential.