Natural Flavans and (Iso)Flavanones with Anticancer Activity: A Review

The present review describes 108 new examples of naturally occurring flavans and flavanones having cytotoxic potential, which have been reported during the period of 2005 to mid-2020. These compounds are found either as aglycones or as glycosides, comprising flavans, flavanones, isoflavanones and miscellaneous flavanones (homo- and bi-flavanones). The main topics addressed in this review are source, structure, and cytotoxic activity in detail and the structure-activity relationship.

Automated summary

This review describes 108 new examples of naturally occurring flavans and flavanones with cytotoxic potential reported from 2005 to mid-2020. These compounds are found in various sources, have diverse structures, exhibit significant cytotoxic activity, and have complex structure-activity relationships.