期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 66, 期 -, 页码 8-14出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2020.08.005
关键词
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资金
- Ministry of Education, Science, Sports and Culture of Japan [19H05651]
- Takeda Science Foundation
- Daiichi Sankyo Foundation of Life Science
- Grants-in-Aid for Scientific Research [19H05651] Funding Source: KAKEN
Centriole duplication occurs once per cell cycle, with the symmetry around the mother centriole needing to be broken for the process to proceed. Plk4 self-assembles into condensates, playing a key role in breaking symmetry and selecting the site for procentriole formation. This dynamic transition contributes to the strict regulation of centriole duplication.
Centriole duplication occurs once per cell cycle. Since only a single daughter centriole is assembled adjacent to each mother centriole, symmetry around the mother centriole must be broken in the process of centriole duplication. Recent studies have established that Plk4, a master kinase for centriole duplication, can self-assemble into condensates, and have suggested that this Plk4 self-assembly is the key to symmetry breaking. Here, we present the current hypotheses for how Plk4 could break symmetry around the mother centriole via autonomous regulation. After this initial symmetry-breaking process, the ring-to-dot conversion of Plk4 around the mother centriole completes the selection of the site for procentriole formation. We also discuss how this dynamic transition contributes to the strict regulation of centriole duplication.
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