Innate immune responses to Listeria in vivo

Listeria monocytogenes (Lm) is a foodborne bacterial pathogen that causes listeriosis, a severe infection that manifests as bacteremia and meningo-encephalitis mostly in immunocompromised individuals, and maternal-fetal infection. A critical pathogenic determinant of Lm relies on its ability to actively cross the intestinal barrier, disseminate systemically and cross the blood-brain and placental barriers. Here we illustrate how Lm both evades innate immunity, favoring its dissemination in host tissues, and triggers innate immune defenses that participate to its control.

Automated summary

Listeria monocytogenes is a foodborne bacterial pathogen that causes severe infection in immunocompromised individuals, crossing various barriers in the body. It evades host innate immunity while triggering innate immune defenses to control its dissemination.