期刊
CURRENT OPINION IN IMMUNOLOGY
卷 68, 期 -, 页码 98-106出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2020.09.006
关键词
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类别
资金
- University of Washington Immunology Training Grant [T32 AI106677]
- N.I.H. [DP2 OD024087, R01 AI145848]
- University of Washington
Tuft cells are rare chemosensory epithelial cells that monitor the environment and initiate immune responses in different tissues based on their unique receptors and effector functions tuned to the surrounding tissue's physiology.
Tuft cells are rare chemosensory epithelial cells that monitor their environment and relay messages to the surrounding tissue via secretion of neuromodulatory and immunomodulatory molecules. In the small intestine tuft cells detect helminth infection, protist colonization, and bacterial dysbiosis, and initiate a type 2 immune response characterized by tissue remodeling. In the airways, tuft cells sense bacteria, allergens, and noxious stimuli and drive evasive behavior, neuroinflammation, and anti-bacterial responses. Here we summarize the most recent tuft cell research and discuss how these findings have provided insight into tuft cell diversity. Built around a core program of chemosensing, tuft cell receptors and effector functions are tuned to the unique environmental exposure and physiology of their surrounding tissue.
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