Inflammasome activation and evasion by bacterial pathogens

Innate immune system plays an essential role in combating infectious diseases by recognizing invading pathogens and activating host defense response. Inflammasomes complexes are a central component of the cytosolic innate immune surveillance and are vital in host defense against bacterial pathogens. Bacterial products or pathogen-induced modifications in the intracellular environment are sensed by the inflammasome receptors that form complexes that serve as a platform for caspase-1-dependent or caspase-11-dependent induction of pyroptosis and secretion of cytokines, IL-1 beta and IL-18. However, several pathogenic bacteria have developed strategies to evade inflammasome activation. This review highlights the recent advances in the mechanism of inflammasome activation by bacterial pathogens and some of the bacterial evasion strategies of inflammasome activation.

Automated summary

The innate immune system plays a crucial role in combating infectious diseases by recognizing invading pathogens and activating host defense response. Inflammasome complexes are central to this process, promoting caspase-1 or caspase-11-dependent induction of pyroptosis and cytokine secretion. Some pathogenic bacteria have developed strategies to evade inflammasome activation.