期刊
CURRENT OPINION IN CELL BIOLOGY
卷 68, 期 -, 页码 37-44出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.08.012
关键词
Mechanosensing; Actin; Arp2/3 complex; Cell migration; Metabolism; Endocytosis
类别
资金
- CRUK core grant [A15673]
- MRC [MR/R017255/1]
The Arp2/3 complex coordinates the formation of branched actin networks, which are sensitive to mechanical forces and allow cells to generate pushing forces, influencing cellular processes.
The Arp2/3 complex orchestrates the formation of branched actin networks at the interface between the cytoplasm and membranes. Although it is widely appreciated that these networks are useful for scaffolding, creating pushing forces and delineating zones at the membrane interface, it has only recently come to light that branched actin networks are mechanosensitive, giving them special properties. Here, we discuss recent advances in our understanding of how Arp2/3-generated actin networks respond to load forces and thus allow cells to create pushing forces in responsive and tuneable ways to effect cellular processes such as migration, invasion, phagocytosis, adhesion and even nuclear and DNA damage repair.
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