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注意：仅列出部分参考文献，下载原文获取全部文献信息。Relaxin and the Cardiovascular System: from Basic Science to Clinical Practice
Rafael Clara Martins et al.
CURRENT MOLECULAR MEDICINE (2020)
Effects of serelaxin in patients admitted for acute heart failure: a meta-analysis
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EUROPEAN JOURNAL OF HEART FAILURE (2020)
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MATRIX BIOLOGY (2020)
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CELLS (2020)
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MOLECULAR ASPECTS OF MEDICINE (2019)
Mechanical regulation of myofibroblast phenoconversion and collagen contraction
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EXPERIMENTAL CELL RESEARCH (2019)
Role of the Hippo Pathway in Fibrosis and Cancer
Cho-Long Kim et al.
CELLS (2019)
Intraarticular injection of relaxin-2 alleviates shoulder arthrofibrosis
William A. Blessing et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
Pardis Pakshir et al.
NATURE COMMUNICATIONS (2019)
AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis
Bryna S. M. Chow et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)
Single chain peptide agonists of relaxin receptors
Praveen Praveen et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)
Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways
Hooi Hooi Ng et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)
Understanding relaxin signalling at the cellular level
Adam L. Valkovic et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)
Mechanisms for the Resolution of Organ Fibrosis
Jeffrey C. Horowitz et al.
PHYSIOLOGY (2019)
TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
Laia Caja et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Resolution of organ fibrosis
Joon-Il Jun et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Inflammation and fibrosis
Matthias Mack
MATRIX BIOLOGY (2018)
The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication
Pardis Pakshir et al.
MATRIX BIOLOGY (2018)
Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling
Giulia Boccalini et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)
Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling
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CELLS (2018)
YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer
Satoshi Noguchi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Relaxin and insulin-like peptide 3 in the musculoskeletal system: from bench to bedside
Alberto Ferlin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1
Alexander I. Agoulnik et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
Anti-fibrotic actions of relaxin
C. S. Samuel et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
Inflammation and metabolism in tissue repair and regeneration
Sabine A. Eming et al.
SCIENCE (2017)
Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-β and Cardiac Fibrosis
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CIRCULATION (2017)
Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions
Lorena Perez et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2017)
Low intensity 635nm diode laser irradiation inhibits fibroblast-myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment
Chiara Sassoli et al.
LASERS IN SURGERY AND MEDICINE (2016)
YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis
Stephen G. Szeto et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)
SINGLE-CHAIN DERIVATIVE OF THE RELAXIN HORMONE IS A FUNCTIONALLY SELECTIVE AGONIST OF THE G PROTEIN-COUPLED RECEPTOR,RXFP1
M. A. Hossain et al.
JOURNAL OF PEPTIDE SCIENCE (2016)
Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin
Veronika Wetzl et al.
FRONTIERS IN PHARMACOLOGY (2016)
The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate
Chao Wang et al.
FRONTIERS IN PHARMACOLOGY (2016)
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
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CHEMICAL SCIENCE (2016)
Tenascin-C May Accelerate Cardiac Fibrosis by Activating Macrophages via the Integrin αVβ3/NuclearFactor-κB/Interleukin-6 Axis
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HYPERTENSION (2015)
Origin of myofibroblasts and cellular events triggering fibrosis
Matthias Mack et al.
KIDNEY INTERNATIONAL (2015)
Role of Sphingosine Kinase/S1P Axis in ECM Remodeling of Cardiac Cells Elicited by Relaxin
Alessia Frati et al.
MOLECULAR ENDOCRINOLOGY (2015)
Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway
X. Zhou et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2015)
Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins
M. Sarwar et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
Cellular Mechanisms of Tissue Fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription
Pei-Suen Tsou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)
Relaxin Modulates Human and Rat Hepatic Myofibroblast Function and Ameliorates Portal Hypertension In Vivo
Jonathan A. Fallowfield et al.
HEPATOLOGY (2014)
New insights into the morphogenic role of stromal cells and their relevance for regenerative medicine. lessons from the heart
Daniele Bani et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2014)
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
Bryna S. Man Chow et al.
KIDNEY INTERNATIONAL (2014)
Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
Michael Zeisberg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)
Role of relaxin-2 in human primary osteosarcoma
Jinfeng Ma et al.
CANCER CELL INTERNATIONAL (2013)
TGF-β1-Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis
Fernanda T. Borges et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)
Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial
John R. Teerlink et al.
LANCET (2013)
Origin and function of myofibroblasts in kidney fibrosis
Valerie S. LeBleu et al.
NATURE MEDICINE (2013)
RELAXIN FAMILY PEPTIDES AND THEIR RECEPTORS
R. A. D. Bathgate et al.
PHYSIOLOGICAL REVIEWS (2013)
Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling
Chiara Sassoli et al.
PLOS ONE (2013)
Relaxin Protects Rat Lungs from Ischemia-Reperfusion Injury via Inducible NO Synthase: Role of ERK-1/2, PI3K, and Forkhead Transcription Factor FKHRL1
Konstantin Alexiou et al.
PLOS ONE (2013)
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1
Jingbo Xiao et al.
NATURE COMMUNICATIONS (2013)
Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention
Livingston Van De Water et al.
ADVANCES IN WOUND CARE (2013)
Relaxin induces matrix-metalloproteinases-9 and-13 via RXFP1: Induction of MMP-9 involves the PI3K, ERK, Akt and PKC-ζ pathways
Nisar Ahmad et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS
Bryna Suet Man Chow et al.
PLOS ONE (2012)
Expression of RXFP1 in skin of scleroderma patients and control subjects
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SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2012)
Origin of myofibroblasts in liver fibrosis
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FIBROGENESIS & TISSUE REPAIR (2012)
Relaxin, Insulin and Diabetes: An Intriguing Connection
Daniele Bani et al.
CURRENT DIABETES REVIEWS (2012)
Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis
Xiangwei Huang et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries via PI3 Kinase and Nitric Oxide
Jonathan T. McGuane et al.
ENDOCRINOLOGY (2011)
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
Jason R. Rock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Antifibrotic Properties of Relaxin: In Vivo Mechanism of Action in Experimental Renal Tubulointerstitial Fibrosis
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ENDOCRINOLOGY (2010)
Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity
Alessandro Pini et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Interaction of Wingless Protein (Wnt), Transforming Growth Factor-beta 1, and Hyaluronan Production in Fetal and Postnatal Fibroblasts
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PLASTIC AND RECONSTRUCTIVE SURGERY (2010)
Recent Advances in Molecular Targets and Treatment of Idiopathic Pulmonary Fibrosis: Focus on TGFβ Signaling and the Myofibroblast
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CURRENT MEDICINAL CHEMISTRY (2009)
Characterization of Relaxin Receptor (RXFP1) Desensitization and Internalization in Primary Human Decidual Cells and RXFP1-Transfected HEK293 Cells
Andras Kern et al.
ENDOCRINOLOGY (2009)
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
Ishanee Mookerjee et al.
FASEB JOURNAL (2009)
The basics of epithelial-mesenchymal transition
Raghu Kalluri et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study
John R. Teerlink et al.
LANCET (2009)
Relaxin and its role in the development and treatment of fibrosis
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TRANSLATIONAL RESEARCH (2009)
Clinical Profile of Relaxin, a Possible New Drug for Human Use
Daniele Bani et al.
CURRENT DRUG SAFETY (2009)
Relaxin as a natural agent for vascular health
Daniele Bani
VASCULAR HEALTH AND RISK MANAGEMENT (2008)
Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling
Lucia Formigli et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2007)
Relaxin Family Peptide Receptors - former orphans reunite with their parent ligands to activate multiple signalling pathways
M. L. Halls et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Matrix elasticity directs stem cell lineage specification
Adam J. Engler et al.
CELL (2006)
Masters and servants of the force: The role of matrix adhesions in myofibroblast force perception and transmission
B Hinz
EUROPEAN JOURNAL OF CELL BIOLOGY (2006)
Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing
Sophia S. Cheon et al.
FASEB JOURNAL (2006)
International union of pharmacology LVII: Recommendations for the nomenclature of receptors for relaxin family peptides
RA Bathgate et al.
PHARMACOLOGICAL REVIEWS (2006)
Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids
Madoka Sato
ACTA DERMATO-VENEREOLOGICA (2006)
Relaxin's physiological roles and other diverse actions
OD Sherwood
ENDOCRINE REVIEWS (2004)
Emerging role of relaxin in renal and cardiovascular function
KP Conrad et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2004)
The sculpturing role of fibroblast-like cells in morphogenesis
F Doljanski
PERSPECTIVES IN BIOLOGY AND MEDICINE (2004)
Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3′,5′-monophosphate by relaxin
BT Nguyen et al.
MOLECULAR ENDOCRINOLOGY (2003)
Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist -: Attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-κB
T Dschietzig et al.
CIRCULATION RESEARCH (2003)
Relaxin gene and protein expression and its regulation of procollagenase and vascular endothelial growth factor in human endometrial cells
S Palejwala et al.
BIOLOGY OF REPRODUCTION (2002)
Activation of orphan receptors by the hormone relaxin
SY Hsu et al.
SCIENCE (2002)
Relaxin activates the MAP kinase pathway in human endometrial stromal cells
Q Zhang et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity
O Bartsch et al.
MOLECULAR HUMAN REPRODUCTION (2001)
Recombinant human relaxin in the treatment of scleroderma - A randomized, double-blind, placebo-controlled trial
JR Seibold et al.
ANNALS OF INTERNAL MEDICINE (2000)
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