期刊
CURRENT GENETICS
卷 67, 期 4, 页码 535-538出版社
SPRINGER
DOI: 10.1007/s00294-021-01167-2
关键词
Histone acetylation; Histone deacetylation; Histone methylation; ING protein
资金
- New Star of Youth Science and Technology of Shaanxi Province [2018KJXX-068]
Histone modifications form networks regulating DNA accessibility and transcription, with ING proteins linked to this process; Fng1 in fungi is involved in crosstalk among histone acetylation, deacetylation, and methylation.
The histone modifications usually form complicated networks to regulate accessibility of DNA and transcription. Identification of proteins that are involved in the crosstalk among different histone modifications will help to better understand the epigenetic regulatory network in eukaryotes. The Inhibitor of Growth (ING) proteins represent a tumor suppressor family were first linked to histone modification in yeast and their functions in epigenetic regulation were further characterized. This review summarizes the crosstalk of histone modification in fungi and describes recently achieved mechanistic insights into the role of Fng1 (an ING protein in filamentous ascomycetes) in this process. We conclude that Fng1 is involved in crosstalk among histone acetylation, deacetylation and methylation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据