Application of Poloxamers for the Development of Drug Delivery System to Treat Leishmaniasis: A Review

Leishmaniasis is a neglected tropical disease affecting more than 1.5 million people annually, with an annual mortality of over 20.000. The drugs used for its treatment are toxic, expensive, require extended treatment times and present variable efficacy. The disease severity and therapy limitations suggest the need for new antileishmanial agents. In this context, in order to identify new options for treatment, a number of studies based on nanotechnological strategies have been carried out. Poloxamers are triblock copolymers very often utilized for nanotherapeutic solutions, resulting in products with better solubility, higher stability, superior therapeutic efficacy and less toxicity. This review will discuss the physicochemical properties of the copolymers, as well as describe the use of poloxamers for the development of therapeutic formulations to treat leishmaniasis.

Automated summary

Leishmaniasis, a neglected tropical disease, affects over 1.5 million people annually with a mortality rate of over 20,000. Current drugs for treatment are toxic and expensive with variable efficacy. Studies on nanotechnological strategies suggest that using poloxamers can improve drug solubility, stability, efficacy, and reduce toxicity for the treatment of leishmaniasis.