期刊
ENDOCRINE REVIEWS
卷 37, 期 1, 页码 62-110出版社
ENDOCRINE SOC
DOI: 10.1210/er.2015-1026
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资金
- Novo Nordisk UK
- Novo Nordisk Australia
- Ipsen
- BBSRC [BBS/E/D/20221657] Funding Source: UKRI
- MRC [MR/N003403/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20221657, 1064045] Funding Source: researchfish
- Medical Research Council [MR/N003403/1] Funding Source: researchfish
Growth failure is frequently encountered in children with chronic inflammatory conditions like juvenile idiopathic arthritis, inflammatory bowel disease, and cystic fibrosis. Delayed puberty and attenuated pubertal growth spurt are often seen during adolescence. The underlying inflammatory state mediated by proinflammatory cytokines, prolonged use of glucocorticoid, and suboptimal nutrition contribute to growth failure and pubertal abnormalities. These factors can impair growth by their effects on the GH-IGF axis and also directly at the level of the growth plate via alterations in chondrogenesis and local growth factor signaling. Recent studies on the impact of cytokines and glucocorticoid on the growth plate further advanced our understanding of growth failure in chronic disease and provided a biological rationale of growth promotion. Targeting cytokines using biological therapy may lead to improvement of growth in some of these children, but approximately one-third continue to grow slowly. There is increasing evidence that the use of relatively high-dose recombinant human GH may lead to partial catch-up growth in chronic inflammatory conditions, although long-term follow-up data are currently limited. In this review, we comprehensively review the growth abnormalities in children with juvenile idiopathic arthritis, inflammatory bowel disease, and cystic fibrosis, systemic abnormalities of the GH-IGF axis, and growth plate perturbations. We also systematically reviewed all the current published studies of recombinanthuman GH in these conditions and discussed the role of recombinanthuman IGF-1.
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