期刊
CRITICAL REVIEWS IN BIOTECHNOLOGY
卷 41, 期 4, 页码 609-627出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07388551.2021.1873239
关键词
Bacillus licheniformis; industry; probiotics; expression platform; bioremediation; enzymes
资金
- Conselleria de Cultura, Educacion e Ordenacion Universitaria, Xunta de Galicia [ED481A-2015/311]
- European project BYEFOULING Low-toxic cost-efficient environment-friendly antifouling materials [612717]
- Xunta de Galicia [ED431B 2020/13]
- BBSRC [BB/R012415/1] Funding Source: UKRI
Bacillus licheniformis is a Gram positive spore-forming bacterial species with high biotechnological potential, used for producing bioactive compounds and bioproducts in various fields. Its applications include probiotics, bioflocculation, biofuel production, and bioremediation among others, but safety concerns exist due to potential transfer of antibiotic resistance genes. Developing a standardized protocol to describe novel strains is crucial for evaluating the biotechnological potential of this species.
Bacillus licheniformis is a Gram positive spore-forming bacterial species of high biotechnological interest with numerous present and potential uses, including the production of bioactive compounds that are applied in a wide range of fields, such as aquaculture, agriculture, food, biomedicine, and pharmaceutical industries. Its use as an expression vector for the production of enzymes and other bioproducts is also gaining interest due to the availability of novel genetic manipulation tools. Furthermore, besides its widespread use as a probiotic, other biotechnological applications of B. licheniformis strains include: bioflocculation, biomineralization, biofuel production, bioremediation, and anti-biofilm activity. Although authorities have approved the use of B. licheniformis as a feed additive worldwide due to the absence of toxigenic potential, some probiotics containing this bacterium are considered unsafe due to the possible transference of antibiotic resistance genes. The wide variability in biological activities and genetic characteristics of this species makes it necessary to establish an exact protocol for describing the novel strains, in order to evaluate its biotechnological potential.
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