期刊
COMPUTERS IN BIOLOGY AND MEDICINE
卷 129, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2020.104170
关键词
Computational modeling; Bone remodeling; Mechanosensing; RPIM; Meshless methods
类别
资金
- Ministerio da Ciencia, Tecnologia e Ensino Superior - Fundacao para a Ciencia e a Tecnologia (Portugal) [SFRH/BD/133105/2017]
- SciTech - Science and Technology for Competitive and Sustainable Industries - Programa Operational Regional do Norte (NORTE2020), through Fundo Europeu de Desenvolvimento Regional (FEDER)
- [MIT-EXPL/ISF/0084/2017]
- [NORTE-01-0145-FEDER-000022]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/133105/2017] Funding Source: FCT
This study numerically describes the bone remodeling process using a novel 2D biomechanical model combined with the Radial Point Interpolation Method (RPIM). The research investigates bone's adaptation to specific loading regimes and the dependence of bone cell signaling pathways on the strain energy density in bone.
Bone remodeling is a highly complex process, in which bone cells interact and regulate bone's apparent density as a response to several external and internal stimuli. In this work, this process is numerically described using a novel 2D biomechanical model. Some of the new features in this model are (i) the mathematical parameters used to determine bone's apparent density and cellular density; (ii) an automatic boundary recognition step to spatially control bone remodeling and (iii) an approach to mimic the mechanical transduction to osteoclasts and osteoblasts. Moreover, this model is combined with a meshless approach - the Radial Point Interpolation Method (RPIM). The use of RPIM is an asset for this application, especially in the construction of the boundary maps. This work studies bone's adaptation to a certain loading regime through bone resorption. The signaling pathways of bone cells are dependent on the level of strain energy density (SED) in bone. So, when SED changes, bone cells' functioning is affected, causing also changes on bone's apparent density. With this model, bone is able to achieve an equilibrium state, optimizing its structure to withstand the applied loads. Results suggest that this model has the potential to provide high quality solutions while being a simpler alternative to more complex bone remodeling models in the literature.
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