期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 199, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111545
关键词
CaCO3 microspheres; Yeast; pH value-sensitive; Anticancer drug carrier
资金
- Natural Science Foundation of China [51503140, 11502158, 11802197, 51502192]
- Shanxi Provincial Key Research and Development Project, China [201803D421060, 201903D421064]
- Shanxi Scholarship Council of China [HGKY2019037]
- Natural Science Foundation of Shanxi Province, China [201901D111077, 201901D111078]
Using Layer-by-Layer self-assembly method, porous calcium carbonate hybrid microspheres (CaCO3-HMPs) were prepared on yeast cells, demonstrating nearly spherical shape with visible pores and good drug release properties. The study indicates the promising application prospects of CaCO3-HMPs as anticancer drug carriers.
Using yeast as organic template and PDDA/PSS with opposite charge as polyelectrolyte, CaCO3 was deposited on yeast cells by Layer-by-Layer self-assembly method, and then porous calcium carbonate hybrid microspheres (CaCO3-HMPs) were prepared by calcination. The CaCO3-HMPs were characterized by FT-IR, XRD, SEM and TG. It was found that the prepared CaCO3-HMPs were nearly spherical, with visible pores on the surface, small particle size uniformity (d = 3 mu m) and good dispersion. Doxorubicin hydrochloride (DOX) was used as the model drug to study drug loading and release properties of CaCO3-HMPs. Then, the drug loading, DOX release under different pH conditions, and the degradation of CaCO3-HMPs under different pH conditions were investigated. The drug release test results showed that the DOX-loaded microspheres released more drugs (99 %) at pH = 4.8 than pH = 7. It indicated that the CaCO3-HMPs were pH sensitive. The cytotoxicity of DOX-loaded microspheres was also studied. It was found that CaCO3-HMPs had good biocompatibility. In addition, compared with DOX group, cytotoxicity test results showed that the DOX-loaded microspheres had the same efficacy but sustained drug release for up to 120 h. Therefore, the CaCO3-HMP microspheres have good application prospects as anticancer drug carriers.
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