期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 199, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111554
关键词
PS-PA6 composite; Electrospinning; Skin patches; Oil carriers; Atopic skin; Controlled oil release
资金
- European Union under the European Regional Development Fund [POIR.04.04.0000-4571/17-00]
- International Centre of Electron Microscopy for Materials Science (IC-EM) at AGH University of Science and Technology
- Sonata Bis 5 project [2015/18/E/ST5/00230]
The study combined electrospinning technology with hydrophobic polystyrene and hydrophilic nylon 6, along with oils, to create patches that effectively moisturize atopic skin. Results showed that these designed patches have a significant moisturizing effect, leading to increased skin hydration.
Atopic dermatitis (eczema), one of the most common disease and also most difficult to treat, is seeking for novel development not only in medicine but also in bioengineering. Moisturization is the key in eczema treatment as dry skin triggers inflammation that damages the skin barrier. Thus, here we combine electrospun hydrophobic polystyrene (PS) and hydrophilic nylon 6 (PA6) with oils to create patches helping to moisturize atopic skin. The fibrous membranes manufactured using electrospinning: PS, PA6, composite PS - PA6 and sandwich system combining them were characterized by water vapor transmission rates (WVTR) and fluid uptake ability (FUA). To create the most effective moisturizing patches we use borage, black cumin seed and evening primrose oil and tested their spreading. We show a great potential of our designed patches, the oil release tests on a skin and their moisturizing effect were verified. Our results distinctly reveal that both fiber sizes and hydrophilicity/hydrophobicity of polymer influence oil spreading, release from membranes and WVTR measurements. Importantly, the direct skin test indicates the evident increase of hydration for both dry and normal skin after using the patches. The electmspun patches based on the hydrophobic and hydrophilic polymers have outstanding properties to be used as oil carriers for atopic dermatitis treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据