Polydopamine-based nanomaterials and their potentials in advanced drug delivery and therapy

Polydopamine (PDA) has shown great potentials in biomedical fields due largely to its unique physicochemical properties, including high photothermal transfer efficiency, excellent drug binding capacity, versatile adhesion ability, sensitive pH responsibility and great biocompatibility and biodegradability. These properties confer PDAbased nanoparticles the potentials either as the drug carriers for advanced drug delivery or as the bioactive agents for photothermal therapy, imaging and biosensing. This review aims to provide a comprehensive understanding of PDA, its polymerization mechanisms and the potentials of PDA-based nano-systems in treating various diseases, including cancer, diabetes, inflammation, bacterial infection and Parkinson's disease. In addition, the concerns of PDA in biomedical use are also discussed.

Automated summary

Polydopamine (PDA) has great potentials in biomedical fields due to its unique physicochemical properties, serving as drug carriers or bioactive agents. This review comprehensively discusses the potentials of PDA-based nano-systems in treating various diseases and addresses concerns in biomedical use.