期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 198, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111456
关键词
Alkyl-pterin; Surface modification; Photosensitive surfaces; Photodynamic inactivation; Staphylococcus aureus
资金
- CONICET [PIP 112-201501-00601CO, PUE 2017 22920170100100CO]
- UNLP [11/X858, 11/X840]
- ANPCyT [PICT-2016-0679, PICT-2016-1424, PICT 2015-1988, PICT 2017-0925]
- CONICET
This study successfully immobilized pterin moieties on silicon substrates through a nucleophilic substitution reaction, with a higher proportion of the N-derivative, retaining their photochemical properties and inhibiting Staphylococcus aureus growth under irradiation. The results suggest the potential for modification of various materials with photosensitive surfaces having microbiological self-cleaning properties.
The tuning of surface properties through functionalization is an important field of research with a broad spectrum of applications. Self-assembled monolayers (SAMs) allow the surface tailoring through the adsorption of molecular layers having the appropriate functional group or precursor group enabling in situ chemical reactions and thus to the incorporation of new functionalities. The latter approach is particularly advantageous when the incorporation of huge groups is needed. In this study, we report the immobilization of pterin moieties on 11-bromoundecyltrichlorosilane-modified silicon substrates based on the in situ replacement of the bromine groups by pterin (Ptr), the parent derivative of pterins, by means of a nucleophilic substitution reaction. The modified surface was structurally characterized through a multi-technique approach, including high-resolution XPS analysis, contact angle measurements, and AFM. The designed synthesis method leads to the functionalization of the silicon surface with two compounds, O-undecyl-Ptr and N-undecyl-Ptr, with a higher proportion of the N-derivative (1:8 ratio). The alkyl-pterins immobilized via the proposed strategy, retain their photochemical properties, being able to inhibit Staphylococcus aureus growth under irradiation (84.3 +/- 15.6 % reduction in viable cells). Our results open the possibility for the modification of several materials, such as glass and metal, through the formation of SAMs having the proper head group, thus allowing the design of photosensitive surfaces with potential microbiological selfcleaning properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据