期刊
BONE
卷 80, 期 -, 页码 60-66出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2015.02.009
关键词
Wnt; Frizzled; Osteoblasts; Satellite stem cells; Muscle; Bone
资金
- Canadian Institutes for Health Research [MOP 81288, MOP 12080]
- Muscular Dystrophy Association [ERA-132935]
- National Institutes of Health [R01AR44031]
- Canadian Stem Cell Network
- Ontario Ministry of Research and Innovation [RE05-084]
- Canada Research Chair Program
- Van Andel Research Institute
- NIH/NIAMS [R01 AR053293]
- Genentech
Wnt signaling plays key roles in many aspects of development. In this review, we will briefly describe the components of signaling pathways induced by Wnt ligands and then describe the current state of research as this applies to aspects of development and disease as it relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and differences in Wnt signaling in these two contexts and how these pathways are being (or could potentially be) targeted for therapeutic treatment of musculoskeletal diseases. This article is part of a Special Issue entitled Muscle Bone Interactions. (C) 2015 Elsevier Inc. All rights reserved.
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