期刊
BONE
卷 78, 期 -, 页码 216-224出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2015.05.016
关键词
Osteoporosis; Epidemiology; Trabecular bone score (TBS); Fragility fracture; Bone mineral density; FRAX
资金
- Alliance for Better Bone Health
- AMGEN
- MSD
- Eli Lilly
- Servier
- Shire
- Consilient Healthcare
- Internis Pharma
- Firefly Pharma
- Medimaps
- GSK
- Danone
- Takeda
- Lilly
- Merck
- Opko Ireland
- GE Healthcare Lunar
- Bayer
- General Electric
- Hologic
- Merck Research Labs
- Novartis
- Novo Nordisk
- Nycomed
- Ono
- Pfizer
- ProStrakan
- Roche
- Sanofi-Aventis
- Tethys
- UBS
- Warner-Chilcott
- Alexion
- Abiogen
- Bruno Farmaceutici
- NPS
- SPA
- Medtronic
- Astalis
- Astra Zeneca
- Ache
- EMS
- Grupogen-AC Farmaceutica
- Hypermarcas
- Sanofi
- Uniao Quimica
- Zodiac
- Negma
- Wyeth
- GlaxoSmithKline
- Merckle
- Theramex
- UCB
- Merck Sharp and Dohme
- Rottapharm
- IBSA
- Genevrier
- Teijin
- Teva
- Ebewee Pharma
- Analis
- Nolver
- Bristol Myers Squibb
- D3A
- Medical Research Council [U1475000001, MC_U147585819, MR/K006312/1, MC_U147585824, G0400491, MC_UU_12011/1, MC_UP_A620_1014, MC_U147585827] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, NF-SI-0508-10082] Funding Source: researchfish
- MRC [MR/K006312/1, MC_U147585819, MC_U147585827, G0400491] Funding Source: UKRI
Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX (R) algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g., diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX. (C) 2015 Elsevier Inc. All rights reserved.
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