The Lymph Node Reservoir: Physiology, HIV Infection, and Antiretroviral Therapy

Despite advances in treatment, finding a cure for HIV remains a top priority. Chronic HIV infection is associated with increased risk of comorbidities, such as diabetes and cardiovascular disease. Additionally, people living with HIV must remain adherent to daily antiretroviral therapy, because lapses in medication adherence can lead to viral rebound and disease progression. Viral recrudescence occurs from cellular reservoirs in lymphoid tissues. In particular, lymph nodes are central to the pathology of HIV due to their unique architecture and compartmentalization of immune cells. Understanding how antiretrovirals (ARVs) penetrate lymph nodes may explain why these tissues are maintained as HIV reservoirs, and how they contribute to viral rebound upon treatment interruption. In this report, we review (i) the physiology of the lymph nodes and their function as part of the immune and lymphatic systems, (ii) the pathogenesis and outcomes of HIV infection in lymph nodes, and (iii) ARV concentrations and distribution in lymph nodes, and the relationship between ARVs and HIV in this important reservoir.

Automated summary

Finding a cure for HIV is still a top priority despite advances in treatment, as chronic HIV infection is linked to an increased risk of comorbidities and the importance of adhering to daily antiretroviral therapy. Viral recrudescence from cellular reservoirs in lymphoid tissues is central to the pathology of HIV, and understanding ARV concentrations and distribution in lymph nodes may explain their maintenance as HIV reservoirs and viral rebound upon treatment interruption.