期刊
CLINICAL LUNG CANCER
卷 22, 期 4, 页码 E637-E641出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.cllc.2020.12.007
关键词
Bioinformatics; Molecular tumor board; Next-generation sequencing; NSCLC; Personalized therapy
类别
资金
- Italian Ministry of Health
In Italy, heterogeneity in molecular assessment of non-small-cell lung cancer (NSCLC) has prompted the Alliance Against Cancer (ACC) to develop a targeted sequencing panel for NSCLC patients, with 1000 metastatic NSCLC patients enrolled in a prospective trial. This trial is part of a nationwide strategy to increase the number of patients with a molecular classification and enhance the genomic profiling capabilities of Italian research institutes.
Background: The deeper knowledge of non-small-cell lung cancer (NSCLC) biology and the discovery of driver molecular alterations have opened the era of precision medicine in lung oncology, thus significantly revolutionizing the diagnostic and therapeutic approach to NSCLC. In Italy, however, molecular assessment remains heterogeneous across the country, and numbers of patients accessing personalized treatments remain relatively low. Nationwide programs have demonstrated that the creation of consortia represent a successful strategy to increase the number of patients with a molecular classification. Patients and Methods: The Alliance Against Cancer (ACC), a network of 25 Italian Research Institutes, has developed a targeted sequencing panel for the detection of genomic alterations in 182 genes in patients with a diagnosis of NSCLC (ACC lung panel). One thousand metastatic NSCLC patients will be enrolled onto a prospective trial designed to measure the sensitivity and specificity of the ACC lung panel as a tool for molecular screening compared to standard methods. Results and Conclusion: The ongoing trial is part of a nationwide strategy of ACC to develop infrastructures and improve competences to make the Italian research institutes independent for genomic profiling of cancer patients.
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